Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses
Identifieur interne : 000785 ( Main/Exploration ); précédent : 000784; suivant : 000786Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses
Auteurs : Tomonori Yaguchi [Japon] ; Asuka Kobayashi [Japon] ; Takashi Inozume [Japon] ; Kenji Morii [Japon] ; Haruna Nagumo [Japon] ; Hiroshi Nishio [Japon] ; Takashi Iwata [Japon] ; Yuyo Ka [Japon] ; Ikumi Katano [Japon] ; Ryoji Ito [Japon] ; Mamoru Ito [Japon] ; Yutaka Kawakami [Japon]Source :
- Cellular and Molecular Immunology [ 1672-7681 ] ; 2017.
Abstract
Immunodeficient mice engrafted with human peripheral blood cells are promising tools for
Url:
DOI: 10.1038/cmi.2017.106
PubMed: 29151581
PubMed Central: 6207709
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000082
- to stream Pmc, to step Curation: 000082
- to stream Pmc, to step Checkpoint: 000201
- to stream Ncbi, to step Merge: 000674
- to stream Ncbi, to step Curation: 000674
- to stream Ncbi, to step Checkpoint: 000674
- to stream Main, to step Merge: 000787
- to stream Main, to step Curation: 000785
Le document en format XML
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<author><name sortKey="Kawakami, Yutaka" sort="Kawakami, Yutaka" uniqKey="Kawakami Y" first="Yutaka" last="Kawakami">Yutaka Kawakami</name>
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<series><title level="j">Cellular and Molecular Immunology</title>
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<front><div type="abstract" xml:lang="en"><p id="Par2">Immunodeficient mice engrafted with human peripheral blood cells are promising tools for <italic>in vivo</italic>
analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, <italic>IL-2rg</italic>
<sup><italic>null</italic>
</sup>
) mice, severe graft versus host disease (GVHD) hinders long term detailed analysis. Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells with little sign of GVHD. Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab, indicating induction of antigen-specific B cells in the NOG-dKO mice. Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells, indicating the induction of antigen-specific T cells in the NOG-dKO mice. Adoptive cell therapies (ACTs) using melanoma antigen recognized by T cells (MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells. ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice, in which changes in human cancer phenotypes by immune intervention, such as increased CD271 expression, could be evaluated. Therefore, NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.</p>
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<tree><country name="Japon"><noRegion><name sortKey="Yaguchi, Tomonori" sort="Yaguchi, Tomonori" uniqKey="Yaguchi T" first="Tomonori" last="Yaguchi">Tomonori Yaguchi</name>
</noRegion>
<name sortKey="Inozume, Takashi" sort="Inozume, Takashi" uniqKey="Inozume T" first="Takashi" last="Inozume">Takashi Inozume</name>
<name sortKey="Ito, Mamoru" sort="Ito, Mamoru" uniqKey="Ito M" first="Mamoru" last="Ito">Mamoru Ito</name>
<name sortKey="Ito, Ryoji" sort="Ito, Ryoji" uniqKey="Ito R" first="Ryoji" last="Ito">Ryoji Ito</name>
<name sortKey="Iwata, Takashi" sort="Iwata, Takashi" uniqKey="Iwata T" first="Takashi" last="Iwata">Takashi Iwata</name>
<name sortKey="Iwata, Takashi" sort="Iwata, Takashi" uniqKey="Iwata T" first="Takashi" last="Iwata">Takashi Iwata</name>
<name sortKey="Ka, Yuyo" sort="Ka, Yuyo" uniqKey="Ka Y" first="Yuyo" last="Ka">Yuyo Ka</name>
<name sortKey="Katano, Ikumi" sort="Katano, Ikumi" uniqKey="Katano I" first="Ikumi" last="Katano">Ikumi Katano</name>
<name sortKey="Kawakami, Yutaka" sort="Kawakami, Yutaka" uniqKey="Kawakami Y" first="Yutaka" last="Kawakami">Yutaka Kawakami</name>
<name sortKey="Kobayashi, Asuka" sort="Kobayashi, Asuka" uniqKey="Kobayashi A" first="Asuka" last="Kobayashi">Asuka Kobayashi</name>
<name sortKey="Morii, Kenji" sort="Morii, Kenji" uniqKey="Morii K" first="Kenji" last="Morii">Kenji Morii</name>
<name sortKey="Nagumo, Haruna" sort="Nagumo, Haruna" uniqKey="Nagumo H" first="Haruna" last="Nagumo">Haruna Nagumo</name>
<name sortKey="Nishio, Hiroshi" sort="Nishio, Hiroshi" uniqKey="Nishio H" first="Hiroshi" last="Nishio">Hiroshi Nishio</name>
<name sortKey="Nishio, Hiroshi" sort="Nishio, Hiroshi" uniqKey="Nishio H" first="Hiroshi" last="Nishio">Hiroshi Nishio</name>
</country>
</tree>
</affiliations>
</record>
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